WebThe present invention relates to immobilized procainamide analogs, as well as to a method of making immobilized procainamide analogs. These immobilized analogs are prepared by activating the carboxyl group on a substituted p-benzoic acid derivative toward nucleophilic attack; reacting the activated benzoic acid derivative with a polyamine to produce the … WebApr 15, 2024 · Most synthetic approaches use two important building blocks, the first type are 4- (4-aminophenyl)morpholin-3-one derivatives 10, which may be an unsubstituted amine or a derivative alkylated on the nitrogen atom (alkyl or COOalkyl group), or a carbamate derived from this derivative.
Solid-Phase Synthesis of Lidocaine and Procainamide
WebA flow-based chemo-enzymatic synthesis of selected APIs (i.e., butacaine, procaine and procainamide) has been developed. A bioreactor made of MsAcT, a versatile acyltransferase from Mycobacterium smegmatis, immobilised on glyoxyl–garose, was exploited to efficiently prepare amide and ester intermediates in gram scale. WebMar 3, 2024 · The adsorption process of procainamide (PA) drug over the Ag- and Au–SiO 2 nanostructure was herein comprehensively investigated using different computational models. The charge distributions of the three modeled configurations indicated a considerable enhancement emanated from a non-covalent type of interaction. hokey pokey elmo toy
A review on the synthetic approaches of rivaroxaban: An …
WebNov 1, 2003 · Building on this approach, Barany and co-workers in 2003 published the synthesis of 60 lidocaine (4) and procainamide (5) analogues from 5- (4-formyl-3,5-dimethoxyphenoxy)pentanoic acid on AM... WebProcainamide is a class 1a antiarrhythmic agent whose primary mechanism is related to its antagonism of cardiac sodium channels delaying phase 0 of the cardiac cycle. … WebMechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of … ho kian seng