Phosphopantetheine binding acp domain

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August undefined, 2024

WebJul 10, 2024 · Acyl carrier proteins (ACPs) involved in fatty acid and polyketide synthesis, our main interest here, carry an acyl group attached to the ppt arm via a thioester linkage. …

Phosphopantetheine binding ACP domain - Wikidata

WebPhosphopantetheine transferases (PPTases) from E. coli (AcpS) and Bacillus subtilis (Sfp) have been used for the enzyme-mediated protein labeling system ( Fig. 5A ). 143 PPTases catalytically transfer 4′-phosphopantetheine from coenzyme A (CoA) to the serine residue of an acyl carrier protein (ACP) or peptidyl carrier protein (PCP). WebThe phosphopantetheine-attachment site (ACP4: S46 and ACP3a: S62) is highlighted with an asterisk. ... The KR-binding epitope of the ACP domain encompasses key residues situated on H I and H II, and combined with previous observations, 17 the ACP domain docks at the same KR C subdomain site in both cis- and trans-AT systems. fisher junior college boston ma

UniProt

WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty … Hei Sook Sul, ... Li Chen, in Progress in Nucleic Acid Research and Molecular … WebChr: 1 Mapping Details/Browsers Description Predicted to enable acyl binding activity and acyl carrier activity. Predicted to act upstream of or within fatty acid biosynthetic process. … Phosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. canadian professional logistics institute

Inhibition of the fungal fatty acid synthase type I multienzyme …

ZFIN Gene: ndufab1a - Zebrafish Information Network

WebPhosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins ... Web210-kDa -chain contains a KS domain, a ketoacyl reductase (KR), and a phosphopantetheine transferase domain. In addi-tion, the -chain includes an N-terminal ACP, required for the … canadian progressive rock groupsWebJul 21, 2024 · The phosphopantetheine-binding domain (PP-binding superfamily), conserved in ACP proteins, is the prosthetic group of ACP, which acts as a linker for the attachment of the activated FA and amino acid groups via a phosphodiester bond (Crawford et al. 2008; Meier et al. 2010; ... canadian progress club halifax

"WebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ( [ACP]) domain. Catalytic activity acetyl-CoA + 2n H+ + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP+ 3 publications " - Phosphopantetheine binding acp domain

Phosphopantetheine binding acp domain

WebNov 20, 2024 · Phosphopantetheine binding ACP domain; Chloramphenicol acetyltransferase-like domain superfamily; 3 more domains. Structure analysis Details. Assembly composition: monomeric . Entry contents: 1 distinct polypeptide molecule. Macromolecule: Linear gramicidin synthase subunit A Chains: A, B. Molecule details › ... WebView Lecture_set+5+lipid+synthesis+notes.pdf from CHEM 153C at UCLA Community School-Los Angeles. The input to fatty acid synthesis is acetyl-CoA, which is carboxylated to malonyl-CoA. The

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WebPhosphopantetheine-binding. Status. UniProtKB unreviewed (TrEMBL) ... Family and domain databases. Gene3D. ... IPR036736 ACP-like_sf; IPR020806 PKS_PP-bd; IPR009081 PP … WebMar 2, 2010 · Phosphopantetheine binding ACP domain Structure analysis Details Assembly composition: monomeric ( preferred) Entry contents: 1 distinct polypeptide molecule Macromolecule: Norsolorinic acid synthase Molecule details › Chain: A Length: 89 amino acids Theoretical weight: 9.43 KDa Source organism: Aspergillus parasiticus

WebPhosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). [1] WebMar 1, 2002 · Furthermore, the helical structure of ACP resembles that of 14-3-3, which suggests that this region of the enzyme may be important in ACP recognition and binding. Therefore, it is likely that the AHL synthase binds acyl-ACP first, followed by a conformational rearrangement of the N-terminal domain and SAM binding in a bi-ter …

The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli. In both cases, the growing chain is bound to the ACP via a thioester derived from the distal thiol of a 4'-phosphopantetheine moiety. WebSep 5, 2008 · FAS inhibitors have demonstrated anti-tumor activity in vivo and in vitro, and in recent years FAS has emerged as an important drug target for the treatment of human …

WebJul 31, 2014 · (1) Movement of the ACP’s phosphopantetheine (Ppant) arm is thought to be coordinated with protein–protein interactions and significant rearrangement of the PKS …

WebFeb 16, 2016 · The selection of the starter unit is generally governed by the substrate specificity of the AT domain in the loading module ().In some modular PKS systems, a didomain-type loading module comprising a loading AT domain and an ACP domain selects an acyl starter building block such as an acetate unit to generate an acyl–ACP … canadian promotional swaghttp://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00823 canadian propeller winnipegWebApr 20, 2024 · ACP-like superfamily, phosphopantetheine binding ACP domain, trimeric LpxA–like superfamily, AMP-dependent synthetase–like superfamily, polyketide synthase, phosphopantetheine-binding domain, AMP-dependent synthetase/ligase: −1.20: −2.32: −1.12: 0.117796: 0.537084: g11299: canadian promissory note template freeWebAn object of the present invention is to provide a microorganism that efficiently produces EPA and a method for producing EPA using the microorganism. The present invention relates to a microorganism having an ability to produce docosahexaenoic acid (DHA), wherein the microorganism contains a protein composed of an amino acid sequence in … canadian propane association ottawaWebJul 22, 2015 · Acyl carrier protein (ACP) Phosphopantetheine binding ACP domain; Structure analysis Details. Assembly composition: monomeric . Entry contents: 1 distinct polypeptide molecule ... Sequence domains: Phosphopantetheine attachment site. Ligands and Environments No bound ligands. No modified residues. canadian proshop online contactWebApr 10, 2024 · HIGHLIGHTS. who: Filamentous Fungi and collaborators from the National Cheng Kung University, Taiwan have published the research work: Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi, in the Journal: (JOURNAL) how: This Tet-On system was applied with A. fumigatus for inducible expression of the gene of … fisher just feels tightWebFeb 20, 2024 · Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to … fisher kaisciai