WebMar 14, 2024 · FGFR2, FGFR3, EGFR, and TRKA increase the cytosolic β-catenin concentration by dissociating β-catenin from cadherin complex through direct phosphorylation at Tyr142 . The ... (AECs) and the phosphorylated β-catenin forms a complex with phospho-SMAD2, resulting in EMT initiation in idiopathic pulmonary fibrosis … WebApr 1, 2008 · FGFR2 -amplified cell lines also contained elevated phosphotyrosine in EGFR, Her2, and Erbb3, but the elevated phosphorylation in EGFR could not be inhibited by gefitinib or erlotinib. We show that the elevated EGFR, Her2, and Erbb3 phosphotyrosine is dependent on FGFR2, revealing EGFR family kinases to be downstream targets of amplified FGFR2.
Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) Polyclonal Antibody
WebThe Phospho-FGFR2 assay is designed for a robust quantification of FGFR2 modulation, phosphorylated on Tyr653 /Tyr654, as a MAPK and pi3/AKT pathway readout. Mutations … Web0.1ml Phospho-FGFR1 (Tyr307) 磷酸化碱性成纤维细胞生长因子受体1抗体 96T/48T 0.1ml Phospho-FGFR1+FGFR2 (Tyr463) 磷酸化碱性成纤维细胞生长因子受体1抗体 96T/48T litigation and arbitration
Phospho-FGFR2 (Tyr586/Tyr588) Antibody Affinity Biosciences
WebFGF activity is mediated by a family of type I transmembrane tyrosine kinases, which undergo dimerization and autophosphorylation after ligand binding. Five distinct genes encode closely related FGF receptors, FGFR1 through 5. FGFRs contain three Ig-like domains and a stretch of acidic residues between the first and second Ig-like domains. WebSep 15, 2024 · Fibroblast growth factor receptor type 2 (FGFR2) has emerged as a key oncogenic factor that regulates gastric cancer (GC) progression, but the underlying mechanism of FGF–FGFR2 signaling pathway ... WebFGFR2 is a member of the fibroblast growth factor receptor family. It is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a central role in the regulation of cell proliferation, differentiation, … litigation and duty to preserve documents